Latest Videos - Project Managers 2018-01-24T07:43:48Z http://network.projectmanagers.net/video/video/rss?xn_auth=no tandem bites tag:network.projectmanagers.net,2017-10-10:1606472:Video:290811 2017-10-10T07:47:12.705Z Candy Swift http://network.projectmanagers.net/profile/CandySwift <a href="http://network.projectmanagers.net/video/tandem-bites"><br /> <img alt="Thumbnail" height="135" src="http://api.ning.com:80/files/PfhqkPs7YPssu72E1GsgPS3VxLVWB9dqQG9wj134JgmMjZ9yRDLia6xtRR-2KRJ0tJEGQsX1QjhFs9uRKEWtPOha7zRLVFoh/tmp315250193497483964.png?width=240&amp;height=135" width="240"></img><br /> </a> <br></br>Bispecific antibodies (BsAbs) are artificial antibodies which possess two distinct specificities. Thereby, it is able to recognize two different antigens or epitopes simultaneously. Taking advantage of this unique character, researchers use BsAbs to guide effectors to targets of interest for further cellular or physiological effects, such as triggering the contacts between immune cells and… <a href="http://network.projectmanagers.net/video/tandem-bites"><br /> <img src="http://api.ning.com:80/files/PfhqkPs7YPssu72E1GsgPS3VxLVWB9dqQG9wj134JgmMjZ9yRDLia6xtRR-2KRJ0tJEGQsX1QjhFs9uRKEWtPOha7zRLVFoh/tmp315250193497483964.png?width=240&amp;height=135" width="240" height="135" alt="Thumbnail" /><br /> </a><br />Bispecific antibodies (BsAbs) are artificial antibodies which possess two distinct specificities. Thereby, it is able to recognize two different antigens or epitopes simultaneously. Taking advantage of this unique character, researchers use BsAbs to guide effectors to targets of interest for further cellular or physiological effects, such as triggering the contacts between immune cells and tumor cells by binding marker proteins on the surface of each cell type simultaneously. Details at <a href="http://www.creativebiolabs.net/bispecific-antibody-fagments-bsab-fragments.htm">http://www.creativebiolabs.net/bispecific-antibody-fagments-bsab-fragments.htm</a>. knob into hole tag:network.projectmanagers.net,2017-10-10:1606472:Video:291004 2017-10-10T07:46:35.659Z Candy Swift http://network.projectmanagers.net/profile/CandySwift <a href="http://network.projectmanagers.net/video/knob-into-hole"><br /> <img alt="Thumbnail" height="135" src="http://api.ning.com:80/files/PfhqkPs7YPsgGb*dWHlRqm-SQ9KeVdVmV4wB3Oekk5FVwtj3lZb8OAmcnxGyZVve5a3Xmkqh8DkK2K-Cj6fg3p9tOiNcQUwP/tmp9080947842243244570.png?width=240&amp;height=135" width="240"></img><br /> </a> <br></br>The knobs-into-holes technique is suitable for heterodimerization immunoglobulin heavy (H) chains with amino acid (AA) changes, which can overcome the mispairing problem. In order to overcome the impurity problem in tri-functional antibody production… <a href="http://network.projectmanagers.net/video/knob-into-hole"><br /> <img src="http://api.ning.com:80/files/PfhqkPs7YPsgGb*dWHlRqm-SQ9KeVdVmV4wB3Oekk5FVwtj3lZb8OAmcnxGyZVve5a3Xmkqh8DkK2K-Cj6fg3p9tOiNcQUwP/tmp9080947842243244570.png?width=240&amp;height=135" width="240" height="135" alt="Thumbnail" /><br /> </a><br />The knobs-into-holes technique is suitable for heterodimerization immunoglobulin heavy (H) chains with amino acid (AA) changes, which can overcome the mispairing problem. In order to overcome the impurity problem in tri-functional antibody production process. her2 cd3 bispecific tag:network.projectmanagers.net,2017-10-10:1606472:Video:291082 2017-10-10T07:45:35.968Z Candy Swift http://network.projectmanagers.net/profile/CandySwift <a href="http://network.projectmanagers.net/video/her2-cd3-bispecific"><br /> <img alt="Thumbnail" height="135" src="http://api.ning.com:80/files/PfhqkPs7YPs6fidxPft-6f8pNupKntZagonEhk5JoOs9aZro13kIKEfUVP-XLHcUK46FHMQhSEXjwtiHOV7DItwU*4DI6WMV/tmp8439520812686337536.png?width=240&amp;height=135" width="240"></img><br /> </a> <br></br>Recombinant Anti-HER2 × Anti-CD3 Bispecific Antibody (Triomab) that maintains an IgG-like shape is a trifunctional, bispecific antibody and a novel tumor targeting agent. This chimera consists of two half antibodies, each with one light and one heavy chain, that originate from two parental antibodies. This bispecific antibody was used in tumor immunotherapy have the unique ability to… <a href="http://network.projectmanagers.net/video/her2-cd3-bispecific"><br /> <img src="http://api.ning.com:80/files/PfhqkPs7YPs6fidxPft-6f8pNupKntZagonEhk5JoOs9aZro13kIKEfUVP-XLHcUK46FHMQhSEXjwtiHOV7DItwU*4DI6WMV/tmp8439520812686337536.png?width=240&amp;height=135" width="240" height="135" alt="Thumbnail" /><br /> </a><br />Recombinant Anti-HER2 × Anti-CD3 Bispecific Antibody (Triomab) that maintains an IgG-like shape is a trifunctional, bispecific antibody and a novel tumor targeting agent. This chimera consists of two half antibodies, each with one light and one heavy chain, that originate from two parental antibodies. This bispecific antibody was used in tumor immunotherapy have the unique ability to recruit T cells toward antigens on the tumor cell surface and, moreover, to activate accessory cells through their immunoglobulin Fc region. It was designed for treatment of ovarian and breast carcinomas. fab arm exchange tag:network.projectmanagers.net,2017-10-10:1606472:Video:291080 2017-10-10T07:44:49.113Z Candy Swift http://network.projectmanagers.net/profile/CandySwift <a href="http://network.projectmanagers.net/video/fab-arm-exchange"><br /> <img alt="Thumbnail" height="135" src="http://api.ning.com:80/files/PfhqkPs7YPsR9EwtD0QSFRMTO6WsODNy0WWYxgYR7ijmXZ*3qLCe-FONo2gbZDAwZd6rvg4qQ*FIPXdyh7YELlQxIvsDKF*V/tmp5806386254684704178.png?width=240&amp;height=135" width="240"></img><br /> </a> <br></br>There are three major steps for the generation of FAE bispecific antibody. Firstly, two IgG antibodies are separately expressed in mammalian cell lines. Meanwhile, a single residue mutation is introduced into the third constant (CH3) domain of each antibody. Then these antibodies are purified through standard protein recovery and purification procedures. Finally, bispecific antibody is… <a href="http://network.projectmanagers.net/video/fab-arm-exchange"><br /> <img src="http://api.ning.com:80/files/PfhqkPs7YPsR9EwtD0QSFRMTO6WsODNy0WWYxgYR7ijmXZ*3qLCe-FONo2gbZDAwZd6rvg4qQ*FIPXdyh7YELlQxIvsDKF*V/tmp5806386254684704178.png?width=240&amp;height=135" width="240" height="135" alt="Thumbnail" /><br /> </a><br />There are three major steps for the generation of FAE bispecific antibody. Firstly, two IgG antibodies are separately expressed in mammalian cell lines. Meanwhile, a single residue mutation is introduced into the third constant (CH3) domain of each antibody. Then these antibodies are purified through standard protein recovery and purification procedures. Finally, bispecific antibody is produced by recombining of these two antibodies. Our FAE bispecific antibody has first-class quality with high yield (typically &gt;95%) which can fully meet your demands. dvd-ig tag:network.projectmanagers.net,2017-10-10:1606472:Video:290999 2017-10-10T07:43:22.085Z Candy Swift http://network.projectmanagers.net/profile/CandySwift <a href="http://network.projectmanagers.net/video/dvd-ig"><br /> <img src="http://api.ning.com:80/files/PfhqkPs7YPv*VsCFerjWNO02IAJ7rxvhMGIyUZXI-IU2FAnwLDXpidSqeF91xtt*satHIbBDoOwqr3PzirxhU2IY6vFtnAAF/tmp4882599229939461649.png?width=240&amp;height=135" width="240" height="135" alt="Thumbnail" /><br /> </a> <a href="http://network.projectmanagers.net/video/dvd-ig"><br /> <img src="http://api.ning.com:80/files/PfhqkPs7YPv*VsCFerjWNO02IAJ7rxvhMGIyUZXI-IU2FAnwLDXpidSqeF91xtt*satHIbBDoOwqr3PzirxhU2IY6vFtnAAF/tmp4882599229939461649.png?width=240&amp;height=135" width="240" height="135" alt="Thumbnail" /><br /> </a>