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Recombinant Anti-HER2 × Anti-CD3 Bispecific Antibody (Triomab) that maintains an IgG-like shape is a trifunctional, bispecific antibody and a novel tumor targeting agent. This chimera consists of two half antibodies, each with one light and one heavy chain, that originate from two parental antibodies. This bispecific antibody was used in tumor immunotherapy have the unique ability to recruit T cells toward antigens on the tumor cell surface and, moreover, to activate accessory cells through their immunoglobulin Fc region. It was designed for treatment of ovarian and breast carcinomas.

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